[HTML][HTML] The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo

AS Siebuhr, D Werkmann, AC Bay-Jensen… - International Journal of …, 2020 - mdpi.com
… -5 versus ADAMTS-4 in human OA cartilage explants [12]. … was assessed in bovine cartilage
and OA human cartilage explants. … ADAMTS-5 in cartilage ex vivo models to characterize its …

Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo

CF Kjelgaard-Petersen, N Sharma, A Kayed… - Biochemical …, 2019 - Elsevier
Bovine cartilage explants were cultured with oncostatin M (… effects on the cartilage ECM,
by measuring the translational … turnover is characterized by cartilage tissue deterioration. This …

[HTML][HTML] Evaluating the inhibition of IL-17A and TNFα in a cartilage explant model cultured with Th17-derived cytokines

SS Groen, AC Bay-Jensen, CS Thudium… - Journal of Translational …, 2024 - Elsevier
… Healthy bovine cartilage explants were cultured with the … 80 C prior to ELISA measurements
and ex vivo experiments. Steps … ) released by the aggrecanases ADAMTS-4 and -5 from the …

[HTML][HTML] Velvet antler polypeptide partially rescue facet joint osteoarthritis-like phenotype in adult β-catenin conditional activation mice

W Xie, Y Zhao, F Li, B Shu, S Lin, L Sun… - … and alternative medicine, 2019 - Springer
… Therefore, we used the mice to model FJ-OA and test the … analysis showed an increase in
total cartilage area after VAP … by down regulate MMP-13, ADAMTS-4 and ADAMTS-5 mRNA …

Alpha 2-macroglobulin as dual regulator for both anabolism and catabolism in the cartilaginous endplate of intervertebral disc

B Huang, J Chen, X Zhang, J Wang, Z Zheng, Z Shan… - Spine, 2019 - journals.lww.com
… In addition, function of α2 M on TNF-α-treated ex vivo IVDs … This study characterized the
changes in expression of α2 M and … Involvement of ADAMTS-5, but not ADAMTS-4, was in the …

Soluble biological markers in osteoarthritis

JC Rousseau, R Chapurlat… - Therapeutic Advances in …, 2021 - journals.sagepub.com
… synthesized cartilage is higher than in the normal cartilagedeveloped specific assays for
the active forms of ADAMTS-4, … models in large and well-characterized prospective studies. …

Nanofibrous hyaluronic acid scaffolds delivering TGF-β3 and SDF-1α for articular cartilage repair in a large animal model

AR Martin, JM Patel, RC Locke, MR Eby, KS Saleh… - Acta biomaterialia, 2021 - Elsevier
… Scaffolds were characterized in vitro and then deployed in a … Future in vitro studies could
use ELISA assays to measure the … that the in vitro assays were performed with bovine MSC's, …

Targeting aggrecanases for osteoarthritis therapy: from zinc chelation to exosite inhibition

D Cuffaro, L Ciccone, A Rossello, E Nuti… - Journal of medicinal …, 2022 - ACS Publications
analysis with a homology model of the ADAMTS4 active site, … compartment, as measured
by magnetic resonance imaging … in IL-1-stimulated bovine cartilage explants (IC 50 value: 22 …

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

Y Hu, Z Gui, Y Zhou, L Xia, K Lin, Y Xu - Free Radical Biology and …, 2019 - Elsevier
… Taken together, considering the pathological characteristics … culture supernatant was measured
using a PGE2 Elisa Kit as … 13 and ADAMTS-4, and reversed cartilage matrix degradation …

[HTML][HTML] Mesenchymal stem cells genetically engineered to express platelet-derived growth factor and heme oxygenase-1 ameliorate osteoarthritis in a canine model

J Oh, YS Son, WH Kim, OK Kwon, BJ Kang - Journal of Orthopaedic …, 2021 - Springer
… matrix (ECM) of the articular cartilage, which leads to pain and … in the expression of ADAMTS-4.
Furthermore, incubation with … rating scale like force plate analysis. Recently, force plate …